X² Clinical Advisory & Compliance
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About

Jessica B. Doto, BSN, MSN, APRN, ANP-C

Adult Nurse Practitioner | Clinical Advisor | Expert Consultant

Jessica is an Adult Nurse Practitioner with more than 25 years of experience across emergency medicine, critical care, hospital medicine, addiction medicine, clinical education, and healthcare operations. She is the Medical Director of Elysara Medical & Wellness with offices in Ithaca and Huntington, New York, where her clinical practice focuses on complex medical optimization, hormone management, metabolic health, infusion medicine, and integrative care. Jessica is also involved in clinical innovation and care-model development in endometriosis through advancing multidisciplinary care and clinical innovation pertaining to this disease. Her work includes the development of expanded models of care designed to address the needs of patients across the surgical and longitudinal course of the disease. She collaborates with clinicians, researchers, and leaders in endometriosis care to translate emerging science and established medical principles into clinical practice. Her approach centers on careful review of the clinical record, current evidence, accepted standards of care, and the practical realities of healthcare delivery.

Jessica B. Doto, BSN, MSN, APRN, ANP-C — Founder, X² Clinical Advisory & Compliance

Credentials & Licensure

Degree

Bachelor of Science in Nursing (BSN); Master of Science in Nursing (MSN)

Certification

Adult Nurse Practitioner — Certified (ANP-C), American Nurses Credentialing Center

Licensure

Advanced Practice Registered Nurse (APRN), New York

Experience

25+ years of clinical practice

Areas of Expertise

  • —Substance use disorder evaluation and addiction medicine
  • —Independent medical and clinical evaluation
  • —Standard-of-care analysis and malpractice review
  • —Emergency medicine and critical care
  • —Hospital medicine and inpatient clinical care
  • —Medication-assisted treatment (MAT/MOUD)
  • —ASAM criteria and level-of-care assessment
  • —Medical direction and clinical compliance
  • —Regulatory and accreditation compliance
  • —Expert consultation and written opinion

Clinical Philosophy

X² was founded on the principle that clinical expertise, applied with rigor and independence, produces better outcomes — for patients, for organizations, and for the legal and regulatory systems that depend on defensible clinical analysis.

Every engagement is approached with the same standard: thorough review of the available evidence, objective analysis grounded in accepted clinical standards, and clear, defensible conclusions. Advocacy has no place in independent clinical review.

Professional Inquiries

Work With X²

X² accepts professional referrals, case review requests, and consulting engagements. To discuss a matter or inquiry:

X² Clinical Advisory & Compliance

Clinical Expertise. Objective Review. Defensible Standards.

© 2026 Jessica Barfield Doto, Nurse Practitioner Adult Health, PLLC D/B/A X² Clinical Advisory & Compliance. All rights reserved.